Non toxic cellular delivery
Because it is based on non-toxic pH-sensitive nanoparticles, CelLuminate™ Red can exploit the natural cellular endocytic pathways to deliver rhodamine-loaded fluorophores vesicles within the cell cytosol – without affecting the cell’s metabolic activity.
CelLuminate Red is non-toxic and non-inflammatory to a wide range of cells, even over extended time periods, as shown below.
Confocal laser scanning microscopy 3D reconstruction of a primary human dermal fibroblast after efficient
cytosolic delivery of rhodamine using CelLuminate Red and staining of the cell’s lysosomes (Lysotracker™ – yellow) and DNA (SYTO9™ – green)
Endosome escape
Effective and rapid internalisation
CelLuminate is non-toxic and non-inflammatory to a wide range of cells, even over extended time periods
Non-cytotoxic
% HDF cell viability over time
Cell viability with variety of cells
Non-inflammatory
Immunolabelling of NFk-B shows CelLuminate does not induce an inflammatory response in cells.
TNF – 10mg/ml
PBS
CelLuminate
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